|
KMID : 0363219950330061079
|
|
Korean Journal of Dermatology
1995 Volume.33 No. 6 p.1079 ~ p.1084
|
|
|
Therapeutic Efficacy of Ciclopirox nail Lacquer in the Treatment of Onychomycoses
|
|
Chun Inn-Ki
|
|
|
Abstract
|
|
|
Background : Ciclopirox 8% nail lacquer is a new topical antifungal agent which is character ized by excellent penetration into the nail plate to the infected doratin and remains there for a prolonged period. We performed a study to assess the
therapeutic efficacy and safety of ciclopirox 8% nail lacquer in the treatment of onychomycoses.
Methods : We used 20 patients with onycomycoses, which was confirmed by KOH and fungus culture. The ciclopirox nail lacquer was applied once daily for 1 month, and followed by two times weekly for the next 5 months. The clinical observation was
performed every month for any clinical improvement and side-dffects. The involved percent of a target nail was measured by using a adhesive tape attached to the selected nail plate. All involved nails(n=68) were also evaluated by a severity
score(sever>50%. Moderate 25-50%, mild<25%).
Results : Seventeen patients were finally assessed because of he deletion of 3 patients through loss of contact. The involved percent of target nail was significantly decreased from 57.4% at baseline to 27.9% through the 6 month-treatment(p<0.01,
ANOVA.) The total reduced precent of target nail involvement at the end of the treatment was 52±22% on average. The precent of severly involved nail(>50%) in all 68 involved nails was also decreased from 56% at baseline to 7% by the end of the treatment. The mycological cure rate was 82.4% by the end of the treatment. The overall efficacy assessed by the physician and patients was improvement by 82.4%. Tolerability was excellent or good in all patients, but cosmetic acceptance was good or excellent by 53%. Only one patient complained of a prickling sensation, but no systemic adverse effects were found.
Conclusion : These data suggest that ciclopirox 8% nail lacquer may be safe and effective in the treatment of onychomycoses. (Kor J Dermatol 1995;33(6) : 1079~1084)
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|